Article: Heterogeneity of spike frequency adaptation among medium spiny neurones from the rat striatum.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Venance L; Glowinski J Neuroscience, 2003
Table 1Passive and active membrane properties of striatal neurones: MSNs, FS and LA interneuronesa
aValues are means±S.E.M. Input resistance (Rin) and membrane time constant (τ) values were measured for hyperpolarization steps of 20–30 pA. The initial firing rate, the f-AHP and s-AHP parameters concern the two first spikes and were measured when injecting 20 to 50 pA above the activation spike threshold. P<0.0001, extremely significant; n.s., not significant; n.d., not determined.
MSNs (n=139) | Non-adapting MSNs (n=100) | Adapting MSNs (n=39) | Non-adapting versus adapting MSNs | Striatal FS interneurones (n=7) | Striatal LA interneurones (n=11) | |
Passive membrane properties | ||||||
RMP, mV | −85.8±0.5 | −85.8±0.7 | −86.0±0.8 | n.s. | −77.0±1.0 | −63.1±3.3 |
Rin, MΩ | 38.3±1.4 | 38.5±1.7 | 37.8±2.7 | n.s. | 167.2±11.9 | 205.0±12.0 |
τ, ms | 32.9±0.9 | 37.4±1.2 | 27.9±0.9 | <0.0001 | 54.7±2.8 | 25.5±2.3 |
Action potentials properties | ||||||
AP threshold, mV | −54.0±0.5 | −55.8±0.7 | −52.2±0.7 | <0.0001 | n.d. | −42.0±1.3 |
AP amplitude, mV | 60.6±0.7 | 62.9±0.8 | 56.0±1.3 | <0.0001 | 61.2±0.5 | 65.1±0.9 |
AP half-amplitude, mV | 46.7±0.6 | 47.4±0.7 | 45.6±1.3 | n.s. | 49.7±0.4 | 51.4±1.4 |
AP duration, ms | 4.4±0.1 | 4.3±0.15 | 4.4±0.3 | n.s. | 1.0±0.02 | 3.1±0.18 |
Half amplitude duration, ms | 1.0±0.04 | 1.0±0.05 | 0.9±0.07 | n.s. | 0.19±0.01 | 0.78±0.09 |
Rise (dV/dt), mV·ms−1 | 52.9±2.1 | 55.7±2.7 | 48.1±2.9 | n.s. | 123.6±4.7 | 75.4±6.3 |
Decay (dV/dt), mV·ms−1 | 8.8±0.4 | 9.0±0.5 | 8.5±0.6 | n.s. | 48.7±2.3 | 6.6±1.6 |
Ratio rise/decay | 6.7±0.2 | 6.7±0.3 | 6.6±0.5 | n.s. | 2.6±0.1 | 14.1±1.42 |
f-AHP peak amplitude, mV | 7.3±0.2 | 7.1±0.2 | 7.8±0.5 | n.s. | 14.6±0.4 | 15.4±0.6 |
f-AHP time to peak, ms | 6.9±0.3 | 6.8±0.3 | 6.8±0.6 | n.s. | 1.1±0.1 | 12.4±1.4 |
f-AHP (dV/dt), mV·ms−1 | 1.41±0.08 | 1.36±0.09 | 1.58±0.18 | n.s. | 1.00±0.16 | 13.73±1.06 |
s-AHP duration, ms | 38.5±1.9 | 37.9±2.3 | 36.8±3.2 | n.s. | 32.1±5.3 | 45.5±12.3 |
s-AHP (dV/dt), mV·ms−1 | 0.28±0.02 | 0.30±0.03 | 0.25±0.02 | n.s. | 0.57±0.09 | 0.44±0.26 |
Action potentials trains | ||||||
Delay to first spike, ms | 324.6±22.0 | 449.3±24.5 | 160.6±18.6 | <0.0001 | n.d. | 230.8±53.2 |
Initial firing rate, Hz | 24.0±1.1 | 19.8±0.9 | 33.5±2.8 | <0.0001 | 62.9±2.5 | 10.1±0.6 |
SFA ratio | 1.53±0.04 | 1.07±0.01 | 2.66±0.09 | <0.0001 | 1.00±0.02 | 1.11±0.02 |