Table 1Passive and active postsynaptic membrane properties of CA1 pyramidal neurons in the 3 different experimental groups.
Cage control (n=10) Mean±SEM
Exercise control (n=7) Mean±SEM
Sleep fragmentation (n=9) Mean±SEM
Property
RMP (mV)
−70.1±1.3
−68.5±1.9
−68.9±0.6
Rin (MΩ)
107±13.7
110±11.1
69.0±6.5*,†
Membrane time constant (ms)
17.3±1.4
15.3±0.7
14.2±1.3
% sag (largest hyperpolarizing step)
15.4±1.8
10.8±1.8
8.2±5.4
AP threshold (mV)
−55.1±0.8
−53.9±0.9
−54.3±1.5
AP amplitude (mV)
79.4±3.9
70.2±3.1
75.7±3.8
AP width (ms)
1.6±0.2
2.0±0.1
1.6±0.1
AHP (mV)
−9.0±1.2
−4.6±1.2*
−8.3±1.1
sAHP (mV)
−7.3±0.7
−6.2±0.5
−6.8±0.8
Initial firing frequency (Hz)
16.6±1.9
13.6±4.2
14.6±1.8
Max firing frequency (Hz)
42.8±6.2
39.3±6.2
40.2±3.8
Property before and during AD (30μM) application
RMP pre-AD (mV)
−69.7±1.9
−66.4±1.5
−68.8±0.5
RMP post-AD (mV)
−74.9±1.8
−70.1±1.5
−71.6±0.7
AD hyperpolarization (mV)
−5.2±0.4
−3.6±0.2*
−2.9±0.3**
Abbreviations: AD=adenosine, AP=action potential, AHP=afterhyperpolarization, RMP=resting membrane potential, Rin=input resistance, sAHP=slow afterhyperpolarization.*Significant difference from cage control (p<0.05).**Significant difference from cage control (p<0.001).†Significant difference from exercise control (p<0.05).
