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Article: Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Brill J; Huguenard JR
Cereb. Cortex, 2010


Table 1

Intrinsic membrane properties

Layer 2/3 Layer 5 Layer 2/3 versus layer 5
Sham (n = 16) FL (n = 16) Sham (n = 16) FL (n = 16)
Resting potential (mV) -67.4 ± 0.8 -66.5 ± 0.5 -56.6 ± 0.8 -55.4 ± 0.8 ****
Input resistance (MΩ) 434 ± 39 367 ± 21 230 ± 22 313 ± 36 -
Capacitance (pF) 336 ± 14 361 ± 11 593 ± 40 530 ± 26 ****
Spike frequency (Hz @ 200 pA) 19.3 ± 0.6 19.9 ± 0.8 15.4 ± 1.3 16.5 ± 0.8 *
AP #1 half width (ms) 1.72 ± 0.6 1.74 ± 0.06 1.48 ± 0.04 1.51 ± 0.04 -
AP #3 half width (ms) 3.21 ± 0.28 2.96 ± 0.17 2.00 ± 0.14 2.09 ± 0.12 ***
AP #1 maximum (mV) 52.5 ± 1.0 53.9 ± 1.3 57.3 ± 1.3 56.4 ± 1.1 -
AP #3 maximum (mV) 36.5 ± 2.7 38.5 ± 1.6 40.5 ± 3.4 41.6 ± 2.0 -
AP threshold (mV) -36.3 ± 0.5 -37.4 ± 0.5 -36.2 ± 0.3 -36.6 ± 0.6 -
Ih at -80 mV (pA) 9.2 ± 2.2 7.5 ± 2.3 96.1 ± 11.6 84.0 ± 11.2 ****

  • Note: AP, action potential. Intrinsic membrane properties of pyramidal cells in layer 2/3 and 5. There were no significant differences between cells of FL and control cortex within each layer. There were significant differences between layer 2/3 and 5 pyramidal cells (right column). *P < 0.05; ***P < 0.001; ****P < 0.0001; -, not significant, P > 0.1. P values were determined for comparisons between control cells, but if no significant difference was detected between cells from FL cortex, the comparison was listed as not significant.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons resting membrane potential (mV) -67.4 ± 0.8 (16) -67.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons resting membrane potential (mV) -56.6 ± 0.8 (16) -56.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons input resistance (MΩ) 434.0 ± 39.0 (16) 434.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons input resistance (MΩ) 230.0 ± 22.0 (16) 230.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons cell capacitance (pF) 336.0 ± 14.0 (16) 336.0 (pF) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons cell capacitance (pF) 593.0 ± 40.0 (16) 593.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons firing frequency 19.3 ± 0.6 (16) 19.3 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons firing frequency 15.4 ± 1.3 (16) 15.4 (Hz) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons spike half-width (ms) 1.72 ± 0.6 (16) 1.72 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons spike half-width (ms) 1.48 ± 0.04 (16) 1.48 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons spike amplitude (mV) 52.5 ± 1.0 (16) 52.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons spike amplitude (mV) 57.3 ± 1.3 (16) 57.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2/3 pyramidal neurons spike threshold (mV) -36.3 ± 0.5 (16) -36.3 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 pyramidal neurons spike threshold (mV) -36.2 ± 0.3 (16) -36.2 (mV) Data Table