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Article: Morphology, electrophysiology and functional input connectivity of pyramidal neurons characterizes a genuine layer va in the primary somatosensory cortex.

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Schubert D; Kötter R; Luhmann HJ; Staiger JF
Cereb. Cortex, 2006


Table 1

Electrophysiological properties of layer Va pyramidal neurons

Va pyramidal neurons RS pyramidal neurons IB pyramidal neurons
(a) Passive intrinsic properties
    n 69 49 20
    Vrmp (mV) -62.8 ± 4.3 -62.6 ± 4.3 -63.3 ± 4.4
    Rin (MΩ) 139.9 ± 55.7 127.8 ± 42.9 169.6 ± 71.7**
    τ (ms) 21.6 ± 8.2 21.2 ± 7.4 22.8 ± 10.0
(b) Active intrinsic properties
    AP threshold (mV) -41.8 ± 5.0 -42.2 ± 4.2 -40.7 ± 6.5
    First AP amplitude (mV) 68.4 ± 12.9 68.1 ± 13.1 69.1 ± 12.7
    Second AP amplitude (mV) 63.5 ± 12.8 67.3 ± 12.6 54.2 ± 7.4**
    First ISI (ms) 39.4 ± 29.1 52.6 ± 24.4 7.6 ± 1.7**
    Second ISI (ms) 70.8 ± 31.3 84.0 ± 23.8 39.2 ± 23.8*
(c) Synaptic inputs following orthodromic electrical stimulation of afferent fibers
    n 28 17 11
    Latency EPSP (ms) 2.5 ± 0.7 2.4 ± 0.5 2.8 ± 1.0
    Latency fast IPSP (ms) 13.4 ± 3.1 (23/28 cells) 13.8 ± 3.4 (16/17 cells) 12.4 ± 2.1 (7/11 cells)
    Latency slow IPSP (ms) 92.8 ± 12.4 (22/28 cells) 89.4 ± 10.9 (14/17 cells) 98.9 ± 13.3 (8/11 cells)
    Vrev fast IPSP (mV) -59.7 ± 3.6 -60.4 ± 2.8 -57.3 ± 5.4
    Vrev slow IPSP (mV) -78.1 ± 5.2 -79.2 ± 4.2 -75.3 ± 6.6

  • Active intrinsic properties were determined by applying suprathreshold depolarizing current pulses at Vrmp eliciting 5-10 APs. Asterisks mark significant differences between RS and IB pyramidal neurons (*P < 0.05, **P < 0.01, ***P < 0.001); data are means ± SD.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5a pyramidal neurons input resistance (MΩ) 139.9 ± 55.7 (69) 139.9 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal regular-spiking neurons input resistance (MΩ) 127.8 ± 42.9 (49) 127.8 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal intrinsically bursting neurons input resistance (MΩ) 169.6 ± 71.7 (20) 169.6 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5a pyramidal neurons membrane time constant (ms) 21.6 ± 8.2 (69) 21.6 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal regular-spiking neurons membrane time constant (ms) 21.2 ± 7.4 (49) 21.2 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal intrinsically bursting neurons membrane time constant (ms) 22.8 ± 10.0 (20) 22.8 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5a pyramidal neurons spike threshold (mV) -41.8 ± 5.0 (69) -41.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal regular-spiking neurons spike threshold (mV) -42.2 ± 4.2 (49) -42.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal intrinsically bursting neurons spike threshold (mV) -40.7 ± 6.5 (20) -40.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5a pyramidal neurons spike amplitude (mV) 68.4 ± 12.9 (69) 68.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal regular-spiking neurons spike amplitude (mV) 68.1 ± 13.1 (49) 68.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal intrinsically bursting neurons spike amplitude (mV) 69.1 ± 12.7 (20) 69.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5a pyramidal neurons resting membrane potential (mV) -62.8 ± 4.3 (69) -62.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal regular-spiking neurons resting membrane potential (mV) -62.6 ± 4.3 (49) -62.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory barrel cortex layer 5b pyramidal intrinsically bursting neurons resting membrane potential (mV) -63.3 ± 4.4 (20) -63.3 (mV) Data Table