Article: Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat.
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Wayman WN; Chen L; Napier TC; Hu XT
Eur. J. Neurosci., 2015
Table 1. Cocaine withdrawal potentiates Tat-induced alterations in membrane properties of mPFC pyramidal neurons Baseline 1.25 nm Tat 2.5 nm Tat 5 nm Tat 10 nm Tat SAL-yoked COC-SA SAL-yoked COC-SA SAL-yoked COC-SA SAL-yoked COC-SA SAL-yoked COC-SA No. of neurons 9 14 9 14 9 14 8 11 8 10 RMP (mV) -69.1 ± 1.0 -64.7 ± 1.1* -68.3 ± 1.5 -63.2 ± 1.2** -67.7 ± 1.9 -58.4 ± 1.3***,## -64.3 ± 1.1*,$ -56.2 ± 1.46***,### -60.1 ± 2.0$ -50.0 ± 2.4**,## R in (MΩ)116.5 ± 13.1 164.2 ± 10.4** 123.6 ± 12.0 178.2 ± 14.9** 128.6 ± 12.6 199.5 ± 19.8*** 133.9 ± 17.8 191.2 ± 16.4** 148.2 ± 16.8 200.8 ± 17.1***,### Rheobase (pA) 141.7 ± 17.2 66.1 ± 7.7*** 127.8 ± 17.4 64.3 ± 7.3*** 108.3 ± 17.2 55.4 ± 7.9*** 81.3 ± 16.1$ 50.0 ± 4.8*** 80.6 ± 19.4$ 40.4 ± 5.6** Threshold (mV) -40.0 ± 1.2 -39.2 ± 2.0 -38.1 ± 1.8 -38.8 ± 1.9 -39.2 ± 1.4 -37.8 ± 2.0 -41.8 ± 1.6 -38.3 ± 2.4 -40.4 ± 0.9 -40.8 ± 4.0 Peak amplitude (mV) 81.2 ± 6.0 70.9 ± 3.3 74.6 ± 5.0 65.6 ± 4.0 72.7 ± 6.7 62.3 ± 4.8 65.7 ± 7.7$ 58.1 ± 6.3# 61.7 ± 7.3$ 59.2 ± 8.1#
Inferred neuron-electrophysiology data values
