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Article: Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hadzipasic M; Tahvildari B; Nagy M; Bian M; Horwich AL; McCormick DA
Proc. Natl. Acad. Sci. U.S.A., 2014

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron adaptation ratio 0.37 ± 0.03 (6) 0.37 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron adaptation ratio 0.31 ± 0.02 (18) 0.31 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron adaptation ratio 0.22 ± 0.01 (11) 0.22 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron adaptation ratio 0.7 ± 0.05 (7) 0.7 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron firing frequency (Hz) 341.0 ± 20.0 (11) 341.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron firing frequency (Hz) 46.0 ± 3.0 (7) 46.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron firing frequency (Hz) 456.0 ± 16.0 (6) 456.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron firing frequency (Hz) 165.0 ± 8.0 (18) 165.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron input resistance (M ohm) 48.0 ± 9.0 (11) 48.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron input resistance (M ohm) 95.0 ± 18.0 (7) 95.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron input resistance (M ohm) 44.0 ± 8.0 (6) 44.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron input resistance (M ohm) 73.0 ± 7.0 (18) 73.0 (MΩ) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron maximum firing rate (Hz) 32.0 ± 2.0 (7) 32.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron maximum firing rate (Hz) 171.0 ± 14.0 (6) 171.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron maximum firing rate (Hz) 50.0 ± 3.0 (18) 50.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron maximum firing rate (Hz) 75.0 ± 5.0 (11) 75.0 (Hz) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron membrane time constant (ms) 6.9 ± 0.7 (18) 6.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron membrane time constant (ms) 4.9 ± 0.7 (11) 4.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron membrane time constant (ms) 8.9 ± 0.9 (7) 8.9 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron membrane time constant (ms) 2.2 ± 0.3 (6) 2.2 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron resting membrane potential (mV) -71.0 ± 1.0 (6) -71.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron resting membrane potential (mV) -69.0 ± 1.0 (18) -69.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron resting membrane potential (mV) -74.0 ± 1.0 (11) -74.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron resting membrane potential (mV) -70.0 ± 1.0 (7) -70.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron sag ratio 18.0 ± 4.0 (11) 0.18 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron sag ratio 19.0 ± 6.0 (7) 0.19 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron sag ratio 4.0 ± 1.0 (6) 0.04 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron sag ratio 11.0 ± 1.0 (18) 0.11 (ratio) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron spike amplitude (mV) 74.0 ± 3.0 (7) 74.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron spike amplitude (mV) 75.0 ± 4.0 (6) 75.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron spike amplitude (mV) 69.0 ± 2.0 (18) 69.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron spike amplitude (mV) 69.0 ± 2.0 (11) 69.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron spike half-width (ms) 0.36 ± 0.03 (11) 0.36 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron spike half-width (ms) 0.26 ± 0.01 (7) 0.26 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron spike half-width (ms) 0.32 ± 0.03 (6) 0.32 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron spike half-width (ms) 0.34 ± 0.03 (18) 0.34 (ms) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 2 motor neuron spike threshold (mV) -50.0 ± 1.0 (18) -50.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 3 motor neuron spike threshold (mV) -50.0 ± 1.0 (11) -50.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 1 motor neuron spike threshold (mV) -50.0 ± 2.0 (7) -50.0 (mV) Data Table
Spinal cord ventral horn motor neuron alpha Spinal cord lumbar ventral horn cluster 4 motor neuron spike threshold (mV) -51.0 ± 2.0 (6) -51.0 (mV) Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Mice
Strain Mice, Transgenic
ElectrodeType Patch-clamp
PrepType in vitro
AnimalAge 75.0
RecTemp 32.0
JxnOffset 8.0
InternalSolution 5.0
ExternalSolution 5.0
JxnPotential Corrected
internal_0_pH 7.25
internal_0_Mg 4.0
internal_0_Na 10.3
internal_0_K 437.0
internal_0_GTP 0.3
internal_0_ATP 4.0
internal_0_HEPES 10.0
internal_0_Cl 7.0
external_0_pH 7.4
external_0_Mg 1.0
external_0_Na 151.25
external_0_K 3.0
external_0_Cl 130.4
external_0_Ca 1.2
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
50034 Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS. Hadzipasic M; Tahvildari B; Nagy M; Bian M; Horwich AL; McCormick DA Proc. Natl. Acad. Sci. U.S.A. 2014 False 10 Shreejoy Tripathy, Athanasios Kritharis, 1